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AC 603 ADVANCED ORGANIC CHEMISTRY                                                                               (3L+1P) I

Objective

To teach stereochemistry, mechanisms of stereospecific and streoselective reactions, reagents in organic synthesis, elucidation of structure of organic compounds.

Theory

UNIT I
  Stereochemistry, Cohn-Ingold-Prelog rules. Inductive, inductomeric, mesomeric and electromeric effects, Walden inversion, asymmetric synthesis, optical resolution, racemic modification.

UNIT II
  Reaction mechanisms – substitution, elimination, addition and condensation reactions.

UNIT III
  Important name reactions and rearrangements.

UNIT IV
  Synthetic reagents and their applications.

UNIT V
  Protective groups in organic synthesis.

UNIT VI
  Photochemistry, pericyclic reactions and sigma tropic rearrangement.

Practicals
  Friedal craft reaction (Alkylation/Acylation), Aldol/Claisen Schmidt reaction, Pechmann condensation/Perkin reaction, Methylation, acetylation, elimination, Oxidation, reduction, hydrolysis, Acid chlorides, amides, esters, Characterisation of Organic compounds (NMR and IR spectroscopy)

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