**DESCRIPTION OF COURSES**

**AS 602 ADVANCED STATISTICAL GENETICS (1L+1P)
(Pre-requisite : AS 566)**

**Objective**

This is an advanced course in Statistical Genetics that aims at describing some advanced level topics for students who wish to pursue research in Statistical Genetics. This course prepares students for undertaking research in this area. This also helps them for applications of this important subject in plant and animal breeding.

**Theory**

UNIT I

Genetic load, random genetic drift, effect of finite population size, Theory of path coefficients. Regular systems of inbreeding.

UNIT II

Effect of inbreeding on quantitative characters. Multiple allelism in continuous variation, sex- linked genes, maternal effects - estimation of their contribution.

UNIT III

Variance component approach and linear regression approach for the analysis of GE interactions. Measurement of stability and adaptability for genotypes. Concepts of general and specific combining ability, diallel and partial diallel crosses: construction and analysis.

**Practicals**

Estimation of genetic load and random genetic drift. Effect of finite population size. Estimation of path coefficients. Detection and estimation of multiple allelism in continuous variation, sex- linked genes, maternal effects. Analysis of G × E interaction, measurement of stability and adaptability. Analysis of data of diallel and partial diallel crosses.

**Suggested Readings**

- Balding, D.J., Bishop, M. and Cannings, C. 2001.
*Handbook of Statistical Genetics*. John Wiley. - Crow, J.F. and Kimura, M. 1970.
*An Introduction to Population Genetics Theory*. Harper and Row. - Dahlberg, G. 1948.
*Mathematical Methods for Population Genetics*. Inter Science Publications. - East, E.M. and Jones, D.F. 1919.
*Inbreeding and Outbreeding*. J B Lippincott Co., London and Philadelphia. - Ewens, W.J. 1979.
*Mathematics of Population Genetics*. Springer. - Falconer, D.S. 1985.
*Introduction to Quantitative Genetics*. English Language Book Society, Longman, - Essex. Fisher, R.A. 1949.
*The Theory of Inbreeding*. Oliver and Boyd. - Fisher, R.A. 1958.
*The Genetical Theory of Natural Selection*. Dover Publication. - Jain, J.P. and Prabhakaran, V.T. 1990.
*Genetics of Populations*. South Asian Publishers Pvt. Ltd. - Jain, J.P. 1982.
*Statistical Techniques in Quantitative Genetics*. Tata McGraw. - Kempthorne, O. 1957.
*An Introduction to Genetic Statistics*. The Iowa State University Press. - Lerner, I.M. 1950.
*Population Genetics and Animal Improvement*. Cambridge University Press.