DESCRIPTION OF COURSES

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AS 602 ADVANCED STATISTICAL GENETICS                       (1L+1P)
(Pre-requisite : AS 566)

Objective
This is an advanced course in Statistical Genetics that aims at describing some advanced level topics for students who wish to pursue research in Statistical Genetics. This course prepares students for undertaking research in this area. This also helps them for applications of this important subject in plant and animal breeding.

Theory

UNIT I
Genetic load, random genetic drift, effect of finite population size, Theory of path coefficients. Regular systems of inbreeding.

UNIT II
Effect of inbreeding on quantitative characters. Multiple allelism in continuous variation, sex- linked genes, maternal effects - estimation of their contribution.

UNIT III
Variance component approach and linear regression approach for the analysis of GE interactions. Measurement of stability and adaptability for genotypes. Concepts of general and specific combining ability, diallel and partial diallel crosses: construction and analysis.

Practicals
Estimation of genetic load and random genetic drift. Effect of finite population size. Estimation of path coefficients. Detection and estimation of multiple allelism in continuous variation, sex- linked genes, maternal effects. Analysis of  G × E interaction, measurement of stability and adaptability. Analysis of data of diallel and partial diallel crosses.

Suggested Readings

  • Li, C.C. 1982. Population Genetics. The University of Chicago Press.
  • Mather, K. 1949. Biometrical Genetics. Methuen.
  • Mather, K. and Jinks, J.L. 1977. Introduction to Biometrical Genetics. Chapman and Hall.
  • Mather, K. and Jinks, J.L. 1982. Biometrical Genetics. Chapman and Hall.
  • Narain, P. 1990. Statistical Genetics. Wiley Eastern Ltd.
  • Narain, P., Bhatia, V.K. and Malhotra, R. 1979. Handbook of Statistical Genetics. IASRI, New Delhi.
  • Singh, R.K. and Chaudhary, B.D. 1979. Biometrical Methods in Quantitative Genetic Analysis. Kalyani Publishers, New Delhi.
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