**DESCRIPTION OF COURSES**

**AS 666 ADVANCED QUANTITAVE GENETICS (2L+1P) III**

**Objective**

This is an advanced course in Quantitative Genetics that aims at describing some advanced level topics for students who wish to pursue research in Statistical Genetics. This course prepares students for undertaking research in this area. This also helps them for applications of this important subject in plant and animal breeding.

**Theory**

UNIT I

Prediction and estimation of genetic merit. Best linear unbiased prediction. Use of mixed model methodology in analysis of animal and plant breeding experiments. Newer reproductive technology and its effect in genetic evaluation of individual merit. Estimation of genetic parameters: problems relating to computational aspects of genetic variance components, parameter estimation in variance component models for binary response data.

UNIT II

Identification of genes with large effects, Use of molecular markers (RFLP, PCR-AFLP, RAPD and SSR), gene mapping and quantitative trait loci. Molecular manipulation for genetic variability.

UNIT III

Survival analysis and concept of censored observation in animal breeding. Phylogeny and analysis of molecular variance. Genetic diversity, Association mapping.

**Practicals**

Prediction and estimation of genetic merit. Best linear unbiased prediction. Use of mixed model methodology in analysis of animal and plant breeding experiments.

**Suggeste****d Readings**

- Balding, D.J., Bishop, M. and Cannigs, C. 2007.
*Handbook of Statistical Genetics*. - John Wiley Crow, J.F. and Kimura, M. 1970.
*An Introduction of Population Genetics Theory*. Harper and Row. - Ewens, W.J. 1979.
*Mathematical Population Genetics*. Springer. - Falconer, D.S. 1985.
*Introduction to Quantitative Genetics*. English Language Book, Longman, Essex. - Fisher, R.A. 1949.
*The Theory of Inbreeding*. Oliver and Boyd. - Fisher, R.A. 1958.
*The Genetical Theory of Natural Selection*. Dover Publication. - Haldane, J.B.S. 1932.
*The Causes of Evolution*. Harper and Bros.. - Jain, J.P. 1982.
*Statistical Techniques in Quantitative Genetics*. Tata McGraw. - Kempthorne, O. 1957.
*An Introduction to Genetic Statistics*. The Iowa State University Press. - Lerner, I.M. 1950.
*Population Genetics and Animal Improvement*. Cambridge University Press. - Lerner, I.M. 1958.
*The Genetic Theory of Selection*. John Wiley. - Li, C.C. 1982
*. Population Genetics*. The University of Chicago Press. - Mather, K. 1951.
*The Measurement of Linkage in Heredity*. Methuen and Co. - Mather, K. and Jinks, J.L. 1982.
*Biometrical Genetics*. Chapman and Hall. - Nagilaki, T. 1992.
*Introduction to Theoretical Population Genetics*. Springer. - Narain, P. 1990.
*Statistical Genetics*. Wiley Eastern Ltd. - Searle, S.R. 1998.
*Variance Components*. John Wiley. - Searle, S.R. 1971.
*Linear Models*. John Wiley.