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BI 510  BIOLOGICAL DATABASES AND DATA ANALYSIS                                                                                 (2L+1P) III

Objective
  To know about different biological databases existing in the public domain and perform analysis on the data available in them.

Theory

UNIT I
  Nature of biological data; Overview of available Bioinformatics resources on the web; NCBI/ EBI/EXPASY etc; Biological Databases: Nucleic acid sequence databases; GenBank/EMBL/ DDBJ; Biological Databases: Protein sequence databases; PIR-PSD; SwissProt, UniProtKB; Database search engines: Entrez, SRS.

UNIT II
  Overview/concepts in sequence analysis; Pairwise sequence alignment algorithms:Needleman & Wunsch, Smith & waterman ; Scoring matrices for Nucleic acids and proteins: MDM, BLOSUM, CSW; Database Similarity Searches: BLAST, FASTA; Multiple sequence alignment: PRAS, CLUSTALW; Biological databases: Genome & genetic disorders;

UNIT III
  Genome databases: Human, model organisms, microbes & viral: OMIM; Biological databases: structural databases: PDB, NDB, CCSD; Derived databases: Prosite, BLOCKS, Pfam/Prodom.

Practicals
  Nucleic acid sequence databases, Protein sequence databases, Database search engines, Database Similarity Searches, Multiple sequence alignment, Genome databases, Structural databases, Derived databases

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