DESCRIPTION OF COURSES
BIO 602 PROTEIN BIOSYNTHESIS (3L+0P) II
To impart knowledge about the various components and processes involved in protein biosynthesis its regulation and the significance of post-translational modifications.
RNA world; Diverse RNA functions in living cells and its significance.
Structure and function of tRNA, rRNA, mRNA; Pre mRNA splicing, tRNA processing, modification and transport.
Structure and function of amino acyl tRNA synthetases; tRNA identity; recognition and charging; proof reading mechanisms.
Protein synthesis: structure and function of ribosomes; Genetic code: Elucidation, nature and properties; Initiation, elongation and termination cycles in prokaryotes and eukaryotes, Protein synthesis inhibitors and regulation.
Secretion and maturation of polypeptides: Signal sequences and secretion; Spontaneous and Chaperone mediated folding and transport to organelles like chloroplast, mitochondria and nucleus; Post translational modifications and their significance.