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BIO 602 PROTEIN BIOSYNTHESIS                                                                               (3L+0P) II

Objective
  To impart knowledge about the various components and processes involved in protein biosynthesis its regulation and the significance of post-translational modifications.

Theory

UNIT I
  RNA world; Diverse RNA functions in living cells and its significance.

UNIT II
  Structure and function of  tRNA, rRNA, mRNA; Pre mRNA splicing, tRNA processing, modification and transport.

UNIT III
  Structure and function of amino acyl tRNA synthetases; tRNA identity; recognition and charging; proof reading mechanisms.

UNIT IV
  Protein synthesis: structure and function of ribosomes; Genetic code: Elucidation, nature and properties; Initiation, elongation and termination cycles in prokaryotes and eukaryotes, Protein synthesis inhibitors and regulation.

UNIT V
  Secretion and maturation of  polypeptides: Signal sequences and secretion; Spontaneous and Chaperone mediated folding and transport to organelles like chloroplast, mitochondria and nucleus; Post translational modifications and their significance.

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