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BIO 604  GENE REGULATION                                                                               (3L+0P) III

Objective
  To provide knowledge about the genome organization, gene expression and regulation in prokaryotes and eukaryotes.

Theory

UNIT I
  Prokaryotic genome organization and gene clustering; Control of gene expression in Prokaryotes: Bacterial RNA polymerase, Promoters and their properties, Operon concept, lac operon, trp operon, ara operon, various controls of gene expression regulation: Autogenous regulation, Attenuation; Patterns of gene expression control in bacteriophage lambda.

UNIT II
  Eukaryotic gene regulation: fundamentals and complexity, Chromatin structure and control of gene expression. Structural motifs in eukaryotic transcription factors.

UNIT III
  RNA editing; RNA-interference; Signal transduction and gene regulation in plant development and stress responses.

UNIT IV
  Epigenetic control of gene expression.

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