DESCRIPTION OF COURSES
GP 540 INTRODUCTION TO BIOINFORMATICS (3L+1P) I
To introduce basic concepts of bioinformatics
History and development of concept of bioinformatics; overview of protein and DNA sequences; sequences databases, retrieval and analysis; methods of sequence alignment - local, global pair wise and multiple alignment; Collection and storage of sequences in the laboratory: DNA sequencing; genomic sequencing; cDNA libraries and sequencing cDNA; processing and submission of sequences; computer storage; sequence formats- Gen Bank, EMBL, NCBI, Stanford
Introduction to database management and DBMS. Introduction to Perl and Bioperl.
Phylogenetic prediction: Phylogeny and sequence variations; concept of evolutionary trees; methods in phylogeny-maximum parsimony, distance methods, maximum likelihood, reliability of prediction.
Gene prediction: Gene structure and characteristics; ORF; methods for microbial and Eukaryotic gene predictions. Internet Resources.
Genome analysis: Genome structure and organization-Prokaryotes and Eukaryotes; sequence assembly and gene identification; methods - comparative genomics, proteomics; synteny, functional genomics.
Sequence searching and alignment, writing programs in Perl for bioinformatics applications, Phylogenetic prediction, gene prediction