DESCRIPTION OF COURSES

Close

GP 603 POPULATION GENETICS                                                                                 (2L+1P) III

Objective
To study the genetic properties of populations and the effect of various evolutionary forces on population genetic parameters.

UNIT -I
Introduction to population genetics; Review of math and probability theory; Measures of genetic variation and genetic distance

UNIT II
Genetic constitution of a population – frequencies of genes and genotypes, Hardy-Weinberg Equilibrium, two alleles, multiple alleles, linkage and sex linked inheritance, HWE testing

UNIT III
Changes of gene frequency under selection, mutation and migration: basic selection model, gametic selection, selection against recessives, dominants and heterozygotes; Allele frequency change caused by mutation, forward and backward mutation, fate of a single mutation, mutation- selection balance; Gene flow and population structure, Continent-Island and general model, Wahlund’s principle, F coefficients.

UNIT IV
Genes in small populations: Genetic drift, inbreeding and effective population size, Founder Effect and Bottlenecks

UNIT V
Linkage Disequilibrium and Association Genetics, Nested Association Mapping (NAM)

Practicals
Exercises on probability, calculation of  genes and genotypic frequencies, testing of  HWE, estimation of allele frequencies under forces of selection, mutation and migration. Inbreeding coefficient and estimation of linkage disequilibrium.

Suggested Readings